一、基本信息
兰文智,男,1973年出生,畲族,西北农林科技大学未来农业研究院教授、博士生导师,植物信号网络前沿交叉研究中心主任。
二、学习经历
1998年-2003年,华中科技大学生物医学工程专业,获工学博士学位;
2003年-2006年,加拿大皇后大学博士后;
2006年-2011年,美国加州大学伯克利分校,博士后/研究员。
三、工作经历
2011年9月-2022年8月,南京大学生命科学学院,教授,博导;
2022年9月-至今,西北农林科技大学未来农业研究院,教授,博导;
四、研究方向
营养是生命活动的物质基础。生物体主要通过质膜和内膜系统感知、转运和分配营养,形成细胞及系统层面的区域化分布,从而提高营养的利用效率和防止外部微生物的侵扰。本课题组以模式植物为研究对象,利用细胞生物学、微生物学、遗传学、生物物理学、生化和分子生物学等多学科方法,深入探讨植物高效利用营养的分子机制,侧重于营养感应及其在体内特定区域的分配,为优质作物的培育提供新基因和新理论。主要研究方向包括:
1. 植物营养分配的分子基础:发掘和鉴定植物控制特定营养跨膜运输的关键转运体;
2. 植物生长所需营养的供应机制:探索植物感知和响应土壤中矿质营养变化的信号途径,以及协调体内营养稳态的机理;
3. 植物营养免疫机制:研究植物如何通过调整营养吸收和分配,以应对微生物的侵染。
五、主持基金
1. 2012年-2015年,主持江苏省特聘教授配套基金,;
2. 2012年-2016年,主持国家自然科学基金面上项目;
3. 2013年-2016年,主持教育部博士点专项科研基金(博导类);
4. 2018年-2021年,主持国家自然科学基金面上项目;
5. 2024年-2026年,主持西北农林科技大学植物营养前沿交叉创新项目;
6. 2025年-2028年,主持国家自然科学基金面上项目;
六、主要学术成果 (*共同第一作者,#共同通讯作者)
1. Shan Z, Chu Y, Sun G, Chen R, Yan J, He Q, Liu Y, Wang B, Luan M#, Lan W#. Mechanisms of vacuolar phosphate efflux supporting soybean root hair growth in response to phosphate deficiency. J Integr Plant Biol. 2024; 66(9): 1983–1999. doi: 10.1111/jipb.13735.
2. Sun G, Luan M#, Xue S, Yan J, Lan W#. Vacuolar H+-ATPase Is Required for Efficient Vacuolar Phosphate Storage and Systemic Pi Homeostasis in Arabidopsis. Plant Cell Environ. 2024 Sep 18. doi: 10.1111/pce.15166.
3. Guan L, Yin L, Liu Y, Yan J, Wang B, Luan M#, Lan W#. A plasma membrane-localized transporter remobilizes aleurone layer magnesium for seed germination in rice. Plant J. 2024; 119(3):1449-1464. doi: 10.1111/tpj.16867.
4. Meng SF*, Zhang B*, Tang RJ, Zheng XJ, Chen R, Liu CG, Jing YP, Ge HM, Zhang C, Chu YL, Fu AG, Zhao FG, Luan S#, Lan WZ#. Four Plasma Membrane-Localized MGR Transporters Mediate Xylem Mg2+ Loading for Root-to-Shoot Mg2+ Translocation in Arabidopsis. Mol Plant. 2022; 5:805–819. doi:10.1016/j.molp.2022.01.011.
5. Zhang B*, Zhang C*, Tang R, Zheng X, Zhao F, Fu A, Lan W#, Luan S#. Two Magnesium Transporters in the Chloroplast Inner Envelope Essential for Thylakoid Biogenesis in Arabidopsis. New Phytol. 2022; 236(2):464-478. doi: 10.1111/nph.18349.
6. Tang RJ*, Meng SF*, Zheng XJ*, Zhang B*, Yang Y, Wang C, Fu AG, Zhao FG, Lan WZ#, Luan S#. Conserved mechanism for vacuolar magnesium sequestration in yeast and plant cells. Nat Plants. 2022; 8(2):181-190. doi: 10.1038/s41477-021-01087-6.
7. Chu M*, Wang Y, Mu B, Ge H, Zhang C, Zhao F, Fu A, Luan S, Li L, Lan W#. An ICln homolog contributes to osmotic and low-nitrate tolerance by enhancing nitrate accumulation in Arabidopsis. Plant Cell Environ. 2021; 44(5):1580-1595. doi: 10.1111/pce.14005.
8. Chu M*, Chen P, Meng S, Xu P, Lan W#. The Arabidopsis phosphatase PP2C49 negatively regulates salt tolerance through inhibition of AtHKT1;1. J Integr Plant Biol. 2021; 63(3):528-542. doi: 10.1111/jipb.13008.
9. Zhang C*, Zhang B*, Mu B, Zheng X, Zhao F, Lan W#, Fu A#, Luan S#. A Thylakoid Membrane Protein Functions Synergistically with GUN5 in Chlorophyll Biosynthesis. Plant Commun. 2020 Jul 3;1(5):100094. doi: 10.1016/j.xplc.2020.100094.
10. Jing Y*, Zheng X*, Zhang D, Shen N, Wang Y, Yang L, Fu A, Shi J, Zhao F, Lan W#, Luan S#. Danger-Associated Peptides Interact with PIN-Dependent Local Auxin Distribution to Inhibit Root Growth in Arabidopsis. Plant Cell. 2019; 31(8):1767-1787. doi: 10.1105/tpc.18.00757.
11. Luan M*, Lan W#. Escape routes for vacuolar phosphate. Nat Plants. 2019; 5(1):9-10. doi: 10.1038/s41477-018-0343-2. (Invited Comment).
12. Zhang F*, Yan X, Han X, Tang R, Chu M, Yang Y, Yang YH, Zhao F, Fu A, Luan S, Lan W#. A Defective Vacuolar Proton Pump Enhances Aluminum Tolerance by Reducing Vacuole Sequestration of Organic Acids. Plant Physiol. 2019;181(2):743-761. doi: 10.1104/pp.19.00626。
13. Zhang B*, Zhang C*, Liu C, Jing Y, Wang Y, Jin L, Yang L, Fu A, Shi J, Zhao F, Lan W#, Luan S#. Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis. Mol Plant. 2018 2;11(7):943-954. doi: 10.1016/j.molp.2018.04.007.
14. Luan M*, Liu J*, Liu Y, Han X, Sun G, Lan W#, Luan S#. Vacuolar Phosphate Transporter 1 (VPT1) Affects Arsenate Tolerance by Regulating Phosphate Homeostasis in Arabidopsis. Plant Cell Physiol. 2018;59(7):1345-1352. doi: 10.1093/pcp/pcy025.
15. Wang Y*, Yang L*, Tang Y, Tang R, Jing Y, Zhang C, Zhang B, Li X, Cui Y, Zhang C, Shi J, Zhao F, Lan W#, Luan S#. Arabidopsis choline transporter-like 1 (CTL1) regulates secretory trafficking of auxin transporters to control seedling growth. PLoS Biol. 2017; 15(12):e2004310. doi: 10.1371/journal.pbio.2004310.
16. Liu J*, Yang L, Luan M, Wang Y, Zhang C, Zhang B, Shi J, Zhao FG#, Lan W#, Luan S#. A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis. Proc Natl Acad Sci U S A. 2015; 112(47):E6571-8. doi: 10.1073/pnas.1514598112.
17. Zhou L*, Lan W*, Chen B, Fang W, Luan S. A calcium sensor-regulated protein kinase, CALCINEURIN B-LIKE PROTEIN-INTERACTING PROTEIN KINASE19, is required for pollen tube growth and polarity. Plant Physiol. 2015;167(4):1351-60. doi: 10.1104/pp.114.256065.
18. Zhou L*, Lan W*, Jiang Y, Fang W, Luan S. A calcium-dependent protein kinase interacts with and activates a calcium channel to regulate pollen tube growth. Mol Plant. 2014;7(2):369-76. doi: 10.1093/mp/sst125.
19. Lee SC*, Lim CW*, Lan W*, He K, Luan S. ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Mol Plant. 2013 Mar; 6(2):528-38. doi: 10.1093/mp/sss078.
20. Lan WZ*, Lee SC*, She YF, Jiang YX, Luan S#. Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA network. Mol Plant 2011;4(3):527-36. doi: 10.1093/mp/ssr031.
21. Lan WZ*, Wang W, Wang SM, Li LG, Buchanan BB, Lin HX, Gao JP, Luan S#. A rice high-affinity potassium transporter (HKT) conceals a calcium-permeable cation channel. Proc Natl Acad Sci U S A. 2010; 107(15):7089-94.
22. Lee SC*, Lan WZ*, Buchanan BB, Luan S# (2009) A protein kinase- phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A,106:21419-21424.
23. Lee SC*, Lan WZ*, Kim BG*, Li LG*, Cheong YH, Pandey GK, Lu G, Buchanan BB, Luan S#. A protein phosphorylation/dephosphorylation network regulates a plant potassium channel. Proc Natl Acad Sci U S A, 2007; 104:15959-15964.
24. Lan WZ, Wang PY, Hill CE. Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C. Am J Physiol Cell Physiol. 2006;291(1):C93-103. doi: 10.1152/ajpcell.00602.2005.
25. Lan WZ, Abbas H, Lemay AM, Briggs MM, Hill CE. Electrophysiological and molecular identification of hepatocellular volume-activated K+ channels. Biochim Biophys Acta. 2005 Mar 1;1668(2):223-33. doi: 10.1016/j.bbamem.2004.12.010.
26. Lan WZ, Abbas H, Lam HD, Lemay AM, Hill CE. Contribution of a time-dependent and hyperpolarization-activated chloride conductance to currents of resting and hypotonically shocked rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2005; 288(2):G221-9. doi: 10.1152/ajpgi.00226.2004.
七、招生学科(专业)
生物学(遗传学)。课题组每年招收多名硕士和博士研究生,热忱欢迎同学们报考。同时,我们也欢迎微生物学、植物生理或病理学、生化和分子生物学相关背景的同学申请课题组的研究助理或博士后职位。
八、联系方式
地址:陕西杨凌西北农林科技大学未来农业研究院
邮编:712100
E-Mail: lanw@nwafu.edu.cn
微信号: Twoplants; 二维码: